Varwere vane kukundikana kwetsvo vanoda nguva dzose dialysis, inova inopindira uye inogona kuva nengozi kurapwa.Asi ikozvino vatsvakurudzi vepaYunivhesiti yeCalifornia, San Francisco (UCSF) vakabudirira kuratidza prototype bioartificial itsvo inogona kuiswa uye kushanda pasina kudiwa kwemishonga.
Itsvo inoita mabasa akawanda akakosha mumuviri, inonyanya kukosha ndeye kusefa chepfu uye tsvina muropa, uye zvakare kugadzirisa BP, electrolyte concentration uye zvimwe zvinwiwa zvemuviri.
Naizvozvo, kana mitezo iyi ikatanga kutadza, zvinonetsa kudzokorora maitiro aya.Varwere vanowanzotanga nedialysis, asi izvi zvinotora nguva uye hazvina kugadzikana.Mhinduro yenguva refu ndeyekugadziriswa kwetsvo, iyo inogona kudzorera hupenyu hwepamusoro, asi inoperekedzwa nekudiwa kwekushandisa immunosuppressive zvinodhaka kudzivirira migumisiro ine ngozi yekuramba.
Kune UCSF itsvo purojekiti, timu yakagadzira itsvo yebioartificial inogona kuiswa muvarwere kuita mabasa makuru ezvinhu chaiwo, asi haidi immunosuppressive mishonga kana kuonda ropa, izvo zvinowanzodiwa.
Chigadzirwa chacho chine zvikamu zviviri zvikuru.Iyo sefa yeropa inoumbwa nesilicon semiconductor membrane, inogona kubvisa tsvina kubva muropa.Panguva imwecheteyo, iyo bioreactor ine enjiniya renal tubular masero anogona kudzora huwandu hwemvura, electrolyte chiyero uye mamwe mabasa emetabolic.Iyo membrane inodzivirirawo masero aya kubva pakurwiswa nesoja remurwere.
Miedzo yakapfuura yakabvumira chimwe nechimwe chezvikamu izvi kuti zvishande zvakazvimirira, asi aka ndekekutanga boka ravaedza kuti vashande pamwe chete mumudziyo.
Itsvo yebioartificial yakabatana netsinga mbiri huru dziri mumuviri wemurwere - imwe inotakura ropa rakasefa ichienda nemuviri uye imwe inotakura ropa rakasefa richidzokera mumuviri - nekudundira, uko tsvina inoiswa seweti.
Chikwata chave kuita ongororo yehumbowo, inoratidza kuti itsvo yebioartificial inoshanda chete pasi peropa uye haidi pombi kana simba rekunze.Masero erenal tubular anorarama uye anoramba achishanda panguva yese yekuyedzwa.
Nekuda kwekuedza kwavo, vaongorori vepaYunivhesiti yeCalifornia, San Francisco vagamuchira mubairo weKidneyX $650,000 semumwe wevakakunda muchikamu chekutanga chemubairo weitsvo.
Shuvo Roy, muongorori anotungamirira wepurojekiti iyi, akati: "Chikwata chedu chakagadzira itsvo yekugadzira inogona kutsigira kurima kwemasero eitsvo dzemunhu pasina kukonzera immune system."Nekugoneka kwemusanganiswa we reactor, tinogona kutarisa kusimudzira tekinoroji yekuomesesa pre-kiriniki yekuongororwa uye pakupedzisira miedzo yekiriniki. "