Vatsvakurudzi kubva kuDhipatimendi reMechanical and Aerospace Engineering (MAE) yeHerbert Wertheim School of Engineering vakagadzira rudzi rutsva rwehemodialysis membrane yakagadzirwa negraphene oxide (GO), inova monoatomic layered material.Zvinotarisirwa kushandura zvachose kurapwa kweitsvo dialysis nemoyo murefu.Kufambira mberi uku kunobvumira iyo microchip dialyzer kuti ibatanidzwe paganda remurwere.Kushanda pasi pekumanikidzwa kwearterial, inobvisa pombi yeropa uye extracorporeal blood circuit, ichibvumira dialysis yakachengeteka mukunyaradza kweimba yako.Kana ichienzaniswa neyepolymer membrane iripo, kupenya kwemembrane mirairo miviri yehukuru hwepamusoro, inoenderana neropa, uye haisi nyore kuyera sema polymer membranes.
Purofesa Knox T. Millsaps weMAE uye muongorori anotungamirira wepurojekiti yemembrane Saeed Moghaddam neboka rake vakagadzira nzira itsva inosanganisira kuzvibatanidza uye optimization yehutano hwepanyama nemakemikari eGO nanoplatelets.Iyi nzira inongoshandura iyo 3 GO mitsara kuita yakanyatso kurongeka nanosheet magungano, nekudaro kuwana ekupedzisira-yepamusoro permeability uye kusarudza."Nekugadzira membrane inokwanisa kupinda mukati kupfuura yainopindirana nayo, iyo glomerular basement membrane (GBM) yeitsvo, takaratidza kugona kukuru kwemananomaterials, nanoengineering, uye molecular self-assembly."Mogda Dr. Mu vakadaro.
Kudzidza kwekuita kwe membrane mune hemodialysis scenarios kwaburitsa mhedzisiro inokurudzira.Iyo sieving coefficients ye urea uye cytochrome-c ndeye 0.5 uye 0.4, zvichienderana, iyo inokwana kwenguva yakareba inononoka dialysis ichichengetedza kupfuura 99% yealbumin;zvidzidzo zvehemolysis, complement activation uye coagulation zvakaratidza kuti zvinofananidzwa nezviripo dialysis membrane zvinhu Kana zvirinani pane kuita kwezviripo dialysis membrane zvinhu.Mhedzisiro yechidzidzo ichi yakaburitswa paAdvanced Materials Interfaces (Kukadzi 5, 2021) pasi pezita rekuti "Trilayer Interlinked Graphene Oxide Membrane for Wearable Hemodialyzer".
Dr. Moghaddam vakati: “Takaratidza imwe yakasarudzika yakagadzirwa neGO nanoplatelet yakaodha mosaic, iyo inofambisira mberi zvikuru nhamburiko yemakore gumi mukugadzirwa kwegraphene-based membranes.”Ipuratifomu inoshanda inogona kusimudzira yakaderera-kuyerera husiku dialysis kumba. ”Dr. Moghaddam parizvino vari kushanda mukugadzira mamicrochips vachishandisa maGO membranes matsva, izvo zvinounza tsvakiridzo pedyo nehuchokwadi hwekupa michina inopfekeka yehemodialysis yevarwere veitsvo.
Chinyorwa cheNature (Kurume 2020) chakati: “World Health Organisation inofungidzira kuti vanhu vangangosvika miriyoni 1.2 vanofa neitsvo gore rega rega [uye kuitika kwechirwere chetsvo (ESRD) kunokonzerwa nechirwere cheshuga neBP]….Dialysis Kubatanidzwa kwezvipimo zvehunyanzvi zvehunyanzvi uye kukwanisa kubhadharira zvinorevawo kuti vasingasviki hafu yevanhu vanoda kurapwa vanokwanisa kuwana.Midziyo inopfekwa-miniaturized yakakodzera mhinduro yehupfumi yekuwedzera mazinga ekupona, kunyanya mukusimudzira China."Membrane yedu chikamu chinokosha cheminiature wearable system, iyo inogona kubereka basa rekusefa kweitsvo, inovandudza zvikuru kunyaradza uye kukwanisa kuwanika pasi rose," akadaro Dr. Moghaddam.
"Kufambira mberi kukuru mukurapa kwevarwere vane hemodialysis uye kutadza kwetsvo kunoganhurwa nehunyanzvi hwemembrane.Tekinoroji yeMembrane haina kufambira mberi zvakanyanya mumakumi mashoma emakore apfuura.Iyo yakakosha kufambira mberi kwe membrane tekinoroji inoda kuvandudzwa kwe renal dialysis.Iyo yakanyanya kupinza uye yakasarudzika Zvishandiso, senge Ultra-yakaonda graphene oxide membrane yakagadzirwa pano, inogona kushandura paradigm.Ultra-yakatetepa permeable membranes haingogone kuona madhiriza madiki, asiwo chaiwo anotakurika uye anopfeka, nekudaro anovandudza hupenyu uye kufungidzira kwemurwere. "James L. McGrath akati iye purofesa we biomedical engineering paYunivhesiti yeRochester uye akabatanidzwa pamwe chete ne-ultra-thin silicon membrane teknolojia yezvinyorwa zvakasiyana-siyana zvehupenyu (Nature, 2007).
Tsvagiridzo iyi yakapihwa mari neNational Institute of Biomedical Imaging uye Bioengineering (NIBIB) pasi peNational Institutes of Health.Dr. Injiniya, Rochester Institute of Technology.Dr. Chung naHayley N. Miller.
Dr. Moghaddam inhengo yeUF Interdisciplinary Microsystems Group uye inotungamirira Nanostructured Energy Systems Laboratory (NESLabs), iyo basa iri kuvandudza ruzivo rwehutano hwe nanoengineering yekushanda kweporous structures uye micro / nanoscale transmission physics.Anounza pamwechete akati wandei maitiro einjiniya nesainzi kuti anzwisise zviri nani fizikisi yemicro/nano-scale transmission uye kugadzira inotevera-chizvarwa zvimiro uye masisitimu ane mashandiro epamusoro uye kugona.
Herbert Wertheim College yeUinjiniya 300 Weil Hall PO Box 116550 Gainesville, FL 32611-6550 Hofisi nhamba yefoni